Dragons Blood Dragons Blood in the prime A in rats in vivo pharmacokinetic study.docVIP

 PAGE \* MERGEFORMAT 10 Dragon’s Blood Dragon’s Blood in the prime A in rats in vivo pharmacokinetic study Of: Yi Jun, Jin description true, Sun Xiaobo, Qiao Shujuan [Abstract] Objective To study the Dragon’s Blood in the loureirin A in rats in vivo pharmacokinetics. Methods by Dragon’s Blood 100 g rats were given 250 mg oral administration, we determined the plasma concentration time points, and 3P97 software to calculate the pharmacokinetic parameters. Results of the Ka of Loureirin A is (1 46 + -0.19) h-1, t1 / 2 (Ka) is (0.48 + -0.06) h, t1 / 2 (K ) is (2.59 + -0.67) h, tmax is (2.00 + -0.55) h, Cmax was (1.13 + -0.24) g mL-1, AUC was (2.84 + -0.68) g h mL-1. Conclusion loureirin A in rats found a compartment open model with linear kinetics, the absorption rapidly. [Keywords:] Dragon’s Blood; loureirin A; performance liquid chromatography; rat; pharmacokinetics Abstract: ObjectiveTo study on pharmacokinetics of loureirin A in rats.Methods The blood samples were collected at a series of time points after an oral administration of Dragon’s blood to rats (2.5 g kg-1), and were analyzed by HPLC. Pharmacokinetic parameters were valuated by 3P97 software. Results Pharmacokinetic parameters of loureirin A were as follows: Ka (1.46 + -0.19) h-1, t1 / 2 (Ka) (0.48 + -0 06) h, t1 / 2 (K ) (2.59 + -0.67) h, tmax (2.00 + -0.55) h, Cmax (1.13 + -0.24) g mL-1, AUC (2.84 + -0.68) g h mL-1.Conclusion The results demonstrated that the pharmacokinetics of loureirin A was consistent with one-compartment model, which was absorbed and distributed rapidly in rats. Keywords:: Dragon’s blood; loureirin A; HPLC; pharmacokinetics Dragon’s blood (Dragon’s blood), also known as Kirin dried up, is the traditional expensive medicine. Domestically, said Dragon’s Blood Dragon’s blood, with blood stasis and pain, bleeding tissue regeneration effect [1], known as “blood holy medicine”, Clinical wide range of applications. Dragon’s Blood of the main components of f