Effects of resveratrol on atherosclerosis apoptosis in rabbit myocardium.docVIP

 PAGE \* MERGEFORMAT 14 Effects of resveratrol on atherosclerosis apoptosis in rabbit myocardium [Abstract] Objective resveratrol (Res) of atherosclerotic rabbit heart mitochondrial apoptosis pathway. Methods 70 healthy male New Zealand white rabbits were randomly divided into 5 groups: normal group, the pathological control group, pathological Res + low-dose group (4 mg kg-1 d-1), the dose of Pathology + Res group (8 mg kg-1 d-1), Pathology Res + high dose group (16 mg kg-1 d-1). sub cage for 12 weeks, take the left ventricular apex myocardium. HE myocardial morphological changes were observed in situ end labeling apoptosis detection apex, semi-quantitative RT-PCR, bax , bcl-2 in the mRNA. Results HE stain obvious morphological changes of cells in each group; pathological apoptosis index higher than the control group, normal group (P lt;0.01) and Res intervention group (P lt;0.01), Res under apoptosis index decreased in a dose dependent manner (P lt;0.05); pathological control group bax, bcl-2 mRNA expression was higher than normal group (P lt;0.01), and join Res intervention, bax expression decreased significantly, bcl -2 expression was increased (P lt;0.01). Conclusion Res can reduce the expression of apoptotic gene bax, increased anti-apoptosis gene bcl-2 expression, reducing Bax/bcl-2 ratio, inhibition of cardiomyocyte apoptosis. [Keywords:] Veratrum alkaloids; atherosclerosis; gene regulation; cardiovascular medicine (TCM); apoptosis; myocardial Many cell and animal studies have shown that resveratrol (Resveratrol, Res) has anti-cancer, anti-thrombotic, anti-allergic, antioxidant and other pharmacological effects [1], is the red wine has a cardiovascular protective effect of the most important material . The author Res discussed preliminary work on the role of vascular endothelial cells and atherosclerotic rabbits improve myocardial fibrosis [2-3]. This study will further explore the Res of atherosclerotic rabbit model of myocardial apoptos