Effects of resveratrol on severe acute pancreatitis injury in rats.docVIP

 PAGE \* MERGEFORMAT 11 Effects of resveratrol on severe acute pancreatitis injury in rats [Abstract] Objective To investigate the effect of resveratrol on severe acute pancreatitis (SAP) rats with brain damage in rats. Methods 96 adult male SD rats were randomly divided into sham operation (SO) group; severe acute pancreatitis (SAP) group; dexamethasone (DEX) treatment group and resveratrol (RES) treatment group. The rats were 3,6,12 h after the collected mold samples. enzyme-linked immunosorbent assay (ELISA) determination serum myelin basic protein (MBP), cell tight junction protein (Zo 1), TNF @, and IL 6 levels; transmission electron microscopy the ultrastructure of pancreas and brain. Results SAP group at all time points and Zo 1 MBP were significantly higher than the SO group (P lt;0.05), RES group and DEX group MBP and Zo 1 levels significantly lower than the SAP group (P lt;0.05). RES group and DEX group TNF @, IL 6 were significantly lower than the SAP group (P lt;0.05). SAP group showed significant neuronal cell swelling, capillary congestion, thrombosis, such as mitochondrial swelling and ultrastructural changes of apoptosis, RES group and the DEX group, these changes significantly reduced. RES group of the Indicators and DEX group was not significant (Pgt; 0.05). Conclusion Zo 1 involved in the degradation of the pathological brain injury in rats SAP process; MBP can serve as a SAP to determine extent of brain damage indicators; resveratrol can reduce brain SAP vascular endothelial damage, which play a role in reducing brain injury in SAP. [Keywords:] severe acute pancreatitis; resveratrol; brain damage ABSTRACT: Objective To explore the protective effect of resveratrol on rat brain injury resulting from severe acute pancreatitis (SAP). Methods Ninety six male Sprague Dawley rats were randomly divided into four groups: sham operation (SO) group, severe acute pancreatitis (SAP) group, resveratrol treated (RES) group and dexamethasone treate