Exogenous vascular endothelial growth factor binding microfracture in the treatment of articular cartilage defects in rabbits.docVIP

 PAGE \* MERGEFORMAT 15 Exogenous vascular endothelial growth factor binding microfracture in the treatment of articular cartilage defects in rabbits Of: initial Tao Chen Qing Hao Qinghai Wei Changhai [Abstract] Objective: To investigate exogenous vascular endothelial growth factor (VEGF) combined with microfracture in the treatment of articular cartilage defect treatment. Methods: 24 healthy New Zealand white rabbits were randomly divided into four groups, making femoral trochlear cartilage defect model, A Group: + collagen sponge microfracture filling adsorption VEGF100g, B group: collagen sponge filling adsorption VEGF100g, C Group: + collagen sponge filling microfracture, D group: collagen sponge filling. taken 16 weeks after surgery specimens, the HE stain, toluidine blue staining, collagen immunohistochemical staining and scanning electron microscope specimens of 16 weeks, cartilage growth. Results: According to Wakitani scoring method to rate of repair of cartilage, the data to D group control group, pairwise comparisons between groups (Dunnett t-tests, A, B, C three groups were statistically significant differences in contrast (P lt;0.01.A, B, C pairwise comparison among the three groups (LSD method, The results showed that group A group B, C difference between the groups was statistically significant (P lt;0.01, while the B group and C was no significant difference between groups (Pgt; 0.05. Conclusion: 1. exogenous VEGF and micro-fracture surgery all can contribute to the body repair cartilage defects, 2. combined with exogenous VEGF can effectively repair microfracture surgery rabbit full-thickness articular cartilage defects, provide a theoretical basis for clinical treatment. [Keywords:] vascular endothelial growth factor, fractures, cartilage [ABSTRACT] Objective: To investigate the experiment on repairing articular cartilage defects by exogenous VEGF in combination with micro-fracture.Methods: 24 healthy New Zealand white rabbits wer