Experimental animal model in spleen Research.docVIP

 PAGE \* MERGEFORMAT 10 Experimental animal model in spleen Research [Keywords:] Animals [Keywords:] model; experimental animals; spleen; Spleen is the body’s largest lymphoid organ, the spleen in the physiology that has blood, storage of blood, filter the blood and destruction of aging cells, while spleen with a specific and non-specific immune function. Spleen are known to have a broad anti-inflammatory and anti-tumor effects [1]. Spleen disease animal model refers to the establishment of medical research that have traumatic and pathologic human spleen disease, animal studies simulated the performance of the objects and related materials, in order to carry out clinical spleen spleen surgery and associated diseases, in-depth study provides the premise of [2]. This article is currently carried out in several major animal models of disease, the spleen to be reviewed. Spleen surgery to retain a functional animal model Canine model of partial splenic resection 1.1 Dog’s spleen vascular distribution has obvious regularity, splenic artery from the spleen into the door a little distance from top to bottom 2: splenic artery and splenic lobe lower lobe artery, respectively, distributed in the spleen, the lower lobe of each leaf is divided into two arteries branch, that is, the upper splenic artery and splenic artery and spleen in the upper middle and lower segment artery and splenic artery lower segment, respectively, each spleen nutrition segment. This leaves in the blood supply of the spleen characterized by splenic lobe resection provides the anatomical basis. Twenty-seven healthy adult dogs, of either sex. According to routine preoperative preparation. With 3% pentobarbital sodium (30 mg / kg) intravenous anesthesia. Fixed on the operating table supine, abdominal skin and regular disinfection of a single shop. OK after the first exploratory laparotomy the liver, gallbladder, spleen. And measure the length of the spleen (normal 15.5 ~ 21.5 cm, an average of 1