Experimental immune infertility research.docVIP

 PAGE \* MERGEFORMAT 15 Experimental immune infertility research Keywords: Immune Keywords:: immune infertility / infertility; experimental study Infertility is a common disease in gynecology, one to the mid-20th century infertility serum lectin found in sperm has been increasing concern immunological infertility. According to statistics, in recent years found in infertility, 20% ~ 40% is due to immune causes [1]. With the development of modern reproductive medicine, experimental research by many scholars to try from a different perspective of the etiology and pathogenesis of this disease, and explore the treatment of this disease. Now about this disease in recent years, experimental studies are summarized below. 1 Pathogenesis Luosong Ping et al [2] In order to clarify serum AsAb effects on sperm function, carried out climb sperm test and wear test eggs. Experimental results show that, after AsAb positive serum treatment, sperm was significantly lower than the uplink high degree of negative serum group and blank group. It also carried out in vitro fertilization ability of sperm, that human sperm hamster egg penetration test. In order to deal with positive serum AsAb sperm, egg further wear tests, the number of sperm capacitation upstream was significantly lower than the control group, slightly lower than the rate of wear egg control group. Tip AsAb primarily affects the upper reaches of the sperm, thereby reducing the chance of pregnancy, the fertilization process may have no significant effect. SUN Xiao-Xi et al [3] In order to observe the transparency of anti-idiotypic antibody with a birth in the IL2, IL4 two kinds of changes in cytokine levels, respectively, with porcine zona pellucida (PZP) anti-mouse anti-PZP monoclonal antibody (17D3mAb) affinity purification The zona pellucida antigens and the unique anti-PZP antibodies (Ab2) mice were immunized with cells induced in vitro were measured in the supernatant IL2 and IL4 conten