Extracorporeal membrane oxygenation and brain injury.docVIP

 PAGE \* MERGEFORMAT 23 Extracorporeal membrane oxygenation and brain injury [Keywords:] extracorporeal membrane oxygenation; cerebral autoregulation capacity; cerebral vascular activity; cerebral oxygen metabolism Brain injury is extracorporeal membrane oxygenation (extracorporeal membrane oxygenation, ECMO) for severe complications, many studies have shown that patients receiving ECMO therapy risk of neurological complications higher than non recipients [1-2]. Lequier et al of the children under 5 years after ECMO support treatment of complications related to the nervous system and found that 12.5% #8203;#8203;occurred in children with cerebral palsy, 62.5% of children diagnosed with behavioral disorders by psychologists [2]. Risnes etc. After reports of adult ECMO, 41% of patients had neuropsychological disorders, 52% of the patients found neuroimaging abnormalities, 41% of patients detected in pathological brain waves [1]. At present, on the ECMO-related generation mechanism of brain damage generally supported the views of the role of various factors involved in cerebral blood flow, cerebral activity, cerebral oxygen metabolism and other mechanisms. 1 ECMO affect the brain 1.1 cerebral autoregulation capacity (cerebral autoregulation, CA) and cerebral blood flow (cerebral blood flow, CBF) CA for the maintenance of cerebral blood flow and metabolic stability is very important. Hypoxia, hypercapnia such circumstances, CA narrowed the brain tissue against a variety of pathological and physiological changes the body (such as low blood pressure) and lower the ability of brain tissue more vulnerable to injury. Many studies have shown that, ECMO impact on CA. Tweed and Short, respectively, found in the long severe hypoxia, CA decreased [3-4], this time with ECMO for treatment and further to the loss of CA [4] Back in 1993, Short and other findings with newborn lambs, intravenous - arterial ECMO (vein-artery ECMO, VA ECMO) support enables CA narrowed