Four Acetylpuerarin simulated human stomach and intestines in the stability of.docVIP

 PAGE \* MERGEFORMAT 9 Four Acetylpuerarin simulated human stomach and intestines in the stability of Of: Chen Guoqing, Zhang Yi, Weng on behalf of the group, Zhou, Du Hongfei, barbarian months, Yang Lu, Yang Dajian [Abstract] Objective To study the four-acetyl puerarin (4ac) in a simulated human gastrointestinal stability of the environment. Methods Determination of the degradation of the remaining percentage 4ac. Results 4ac in 0.062 5 ~ 1.0 mg / ml concentration range good linearity in the average recovery was 101.05% (RSD = 1.59%). artificial intestinal fluid (without enzyme and enzyme) and, 4ac at room temperature 25 ℃ and 37 ℃, more stable; artificial gastric fluid (without enzyme and enzyme ) and, 4ac at 25 ℃ and 37 ℃ unstable, half life 18.99,9.76,13.33 h and 8.22 h. Conclusion 4ac good stability in artificial intestinal juice, can be developed enteric-coated formulations. [Keywords:] Four Acetylpuerarin; stability; artificial gastric juice; artificial intestinal juice; high performance liquid chromatography Abstract: ObjectiveTo study the stability of tetraacetyl-puerarin (4ac) in artificial gastric juice and intestinal juice. MethodsThe degrading content of 4ac was determined by HPLC.ResultsThe linear range of 4ac was good between 0.062 5 and 1.0mg/ml, recovery was 101.05 % (RSD = 1.59%). 4ac was stable in artificial intestinal juice (including with enzyme) at 25 ℃ and 37 ℃. T1 / 2 of 4ac was 18.99,9.76,13.33 h and 8.22 h in artificial gastric juice (including with enzyme ) at 25 ℃ and 37 ℃. ConclusionIt is stable in artificial intestinal juice and can be developed enteric preparation. Keywords:: Tetraacetyl-puerarin; Stability; Artificial gastric juice; Artificial intestinal juice; HPLC Puerarin puerarin cardiovascular activity is the main substances [1,2], used clinically in the treatment of coronary heart disease, angina pectoris and cerebral thrombosis and other diseases [3,4]. Experiments show that dog oral bioavailability of pu