Healthy human body lactate tablets of levofloxacin pharmacokinetics and bioequivalence studies.docVIP

 PAGE \* MERGEFORMAT 6 Healthy human body lactate tablets of levofloxacin pharmacokinetics and bioequivalence studies [Keywords:] lactate levofloxacin tablets; pharmacokinetics; chromatography, high pressure liquid; bioequivalence [Keywords:] lactate levofloxacin tablets; pharmacokinetics; chromatography, high pressure liquid; bioequivalence Levofloxacin Lactate is China’s newly developed third-generation quinolone antibacterial drug, for ofloxacin isomers, with a broad spectrum anti-bacterial, anti-bacterial effect stronger and so on. Its antibacterial activity of optical enantiomers D-type 8128 times raceme OFLX 2 times. the light of literature [1-3], we have established a reversed-phase high performance liquid chromatography determination of levofloxacin in plasma lactate concentration method, 18 healthy volunteers two kinds of self-cross of oral levofloxacin lactate tablets after the pharmacokinetics and bioavailability were analyzed and compared. 1 Materials and methods 1.1 Reference material preparation: lactic acid, levofloxacin tablets (to Ericsson films, Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory production, specification 0.1 g / tablets, batch number 040,478); test formulation: lactic acid, levofloxacin tablets (Tianjin Pharmaceutical Group, New Cheng Co., Ltd. to provide, specifications 0.1 g / tablets, batch number 030,928); Levofloxacin Lactate reference substance: China’s pharmaceutical and biological products to offer batch 130,455,200,202. Methanol (GR Beijing Chemical Plant, batch number 20,020,629), tetrabutylammonium bromide of ammonia: analytically pure, Tianjin Kermel Chemical Reagent Development Center, batch number 20,040,531, dichloromethane (AR. Beijing Chemical Plant, batch number 20,030,319). Shimadzu LC10A high-performance liquid chromatography, including LC10A high-pressure infusion pump, LC10AV tunable UV detector, CTO10A column temperature box 7125 manual injection valve, analysis Star chromatography worksta