Hepatitis E virus IgA antibodies in Progress.docVIP

 PAGE \* MERGEFORMAT 20 Hepatitis E virus IgA antibodies in Progress Of: the more the ball Lusong Yao Liang Limin Zhou [Abstract] HEV (Hepatitis E, HE) by the hepatitis E virus (Hepatitis E virus, HEV) transmitted through the digestive tract caused by acute infectious diseases, the incidence rate increases, the incidence is currently no specific treatment, but also No specific passive and active immunization for the prevention agents. In patients with acute hepatitis E, HEV RNA in blood or stool short duration, the operation is complicated and costly, not widely carried out in clinical. HE The diagnosis mainly depends on the serum HEV antibodies, anti-HEV IgM is the diagnosis of HE indicator of acute infection, the presence of rheumatoid factor will affect the detection of serum IgM, resulting in false positives. anti-HEV IgG usually 2 weeks after the onset of detectable, sustainable 1 year or even years, so anti-HEV IgG can not distinguish patients with acute HEV infection or past infection. Research has shown that anti-HEV IgA is the target of acute HE may replace or complement existing diagnostic reagents for HE diagnosis of IgM, both increase detection specificity, but also effective in reducing misdiagnosis. [Keywords:] hepatitis E, hepatitis E virus, anti-HEV IgM, anti-HEV IgA, anti-HEV IgG [Abstract] Hepatitis E (HE), as the spread of acute gastrointestinal disease, is caused by hepatitis E virus (HEV). Its morbidity is increasing year and year.However, there is neither specific treatment nor specific passive and active immunity drug to prevent against the disease at present.HEV RNA in blood or stool of patients with acute Hepatitis E can not be widely used due to its short existed time, complicated operation and high cost.Diagnosis of Hepatitis E is made by detection of serum anti-HEV antibody.Anti-HEV IgM is a diagnosis index of acute Hepatitis E, which may be influenced by rheumatoid factor, resulting in false positive.Anti-HEV IgG can gen