HPLC Determination of compound levels of methyl salicylate liniment.docVIP

 PAGE \* MERGEFORMAT 10 HPLC Determination of compound levels of methyl salicylate liniment [Abstract] Objective using high performance liquid chromatography compound content of methyl salicylate liniment. Methods sodium octane  acetonitrile gradient elution solution, Kromasil C18 column (250 mm * 4.6 mm, 5 μ m) as stationary phase, flow rate of 1.2 mL / min, detection wavelength was 280 nm. Results chlorpheniramine maleate in the 19.96 ~ 399.22 μ g / mL range a good linear relationship, the average recovery was 100.0%, RSD 1.2%; Azelaic acid amide in the fragrant blue 1.967 ~ 39.34 μ g / mL range a good linear relationship The average recovery was 100.8%, RSD of 1.3%. Conclusion The method is simple, high sensitivity, can be used for compound determination of methyl salicylate liniment. [Keywords:] compound methyl salicylate liniment; Chlorpheniramine maleate; Wang Xiang Lan acid amide; high-performance liquid chromatography; determination Abstract: Objective To develop an HPLC method for analyzing the contents of active ingredients in compound methyl salicylate liniment.Methods Samples were analyzed on a Kromasil C18 column (250 mm * 4.6 mm, 5 μ m) with a linear gradient elution mode using sodium octanesulfonate and acetonitrile as eluents.The flow rate was 1.2 ml / min.UV detection wavelength was set 280 nm. Results Chlorphenamine maleate had a good linearity in the range of 19.96 ~ 399.22 μ g / mL with average recovery of 100.0% and RSD of 1.2%. Pelargonic acid vanillylamide had a good linearity in the range of 1.967 ~ 39.34 μ g / mL with average recovery of 100.8% and RSD of 1.3%. Conclusion The method is simple, sensitive and rapid. Keywords: compound methyl salicylate liniment; chlorphenamine maleate; pelargonic acid vanillylamide; HPLC Compound, also known as methyl salicylate liniment an Merlot, is Japan’s Kobayashi Pharmaceutical Co., Ltd. products, Pharmaceutical Technology Co., Ltd. from Beijing Yi Pudi declare imported drug registration. Com