Hydroxyapatite containing vancomycinDevelopment of anti-infective titanium plate.docVIP

 PAGE \* MERGEFORMAT 17 Hydroxyapatite containing vancomycinDevelopment of anti-infective titanium plate Of: Tangliang Hua, Zhao Changhong, Pan Changjiang, Yuan-Liang Wang, Aimin [Abstract] Objective To explore a carry and release of vancomycin (VCM’s anti-infective preparation of internal fixation plate, and by scanning electron microscopy (SEM), X-ray energy dispersive spectroscopy (EDX), infrared spectroscopy (FT characterized by IR and other testing, antimicrobial assay of its inhibitory effect on Staphylococcus aureus, etc., hoping for the clinical prevention and treatment of bacterial infection after open fracture surgery to provide a way. Methods of hydroxyapatite (HA as vector, using bionic solutions (Simulated body fluid, SBF growth method (Biomimetic growth, the titanium plate were prepared substrate surface carrying the HA anti-infective coating VCM, through SEM, EDX and FT IR detection methods such as surface coating on the titanium plate layer testing, selection of Staphylococcus aureus (S.aureus as the test bacteria were observed release contains VCM-HA HA titanium plate and titanium plate containing antibacterial effect in vitro. The results obtained on the surface plate containing VCM HA coatings, antibacterial test show significant inhibition zone around the plate, indicating that the VCM is successfully carrying on the coating. conclusions of the VCM HA titanium plate can effectively carry vancomycin, and maintained its antibacterial activity. [Keywords:] Bionic vancomycin plates of hydroxyapatite coating solution S. aureus Abstract:: Objective To explore the preparation of an internal fixation plate which can inhibit infection by carrying and slow releasing vancomycin.By detecting inhibition of staphylococcus aureus in vitro, we hope to provide a way to prevent and treat bacterial infection after surgery of open fractures . Methods HA coatings which carry vancomycin were prepared on the surface of titanium plate substrate for fr