Hydroxyapatite repair of mandibular defect.docVIP

 PAGE \* MERGEFORMAT 8 Hydroxyapatite repair of mandibular defect [Abstract] conducted in two nano-hydroxyapatite bone repair in rabbits. Experiments show that the Nano-HA has good biocompatibility and biodegradability, as the multi-center bone, involved in bone metabolism, and its absorption rate and the organization grow into the same speed, and 750Nano-HA than 70Nano-HA. [Keywords:] nano-hydroxyapatite; bone defect; bone formation; biodegradation In this study, two kinds of nano-hydroxyapatite on the repair of rabbit mandibular defects research, verification is better than ordinary hydroxyapatite hydroxyapatite hydroxyapatite nano-materials for the clinical application of theoretical basis. 1 Materials and methods 1.1 Materials Nano-HA by the Institute of Materials Engineering, Jiamusi University, provides (70Nano-HA, 750Nano-HA. Commercially available hydroxyapatite (HA), conventional and sterilized. 1.2 Group 30 rabbits were randomly divided into 750Nano-HA group, 70Nano-HA group and the HA group. After sampling time was 4 weeks, 12 weeks, 20 weeks. 1.3 Sumianxin implants to the animals injected with anesthesia, the surgical drape routine disinfection, along the midline incision under the chin rabbit subcutaneous tissue in the mandibular body were exposed, and saline cooled dental drill in the body in the mandibular third 1.0cm in diameter, made of a bone defect through to retain the lingual periosteum. lavage area, stop the bleeding. to spare 750Nano-HA, 70Nano-HA and HA implanted in bone defects after reconciliation, closing the wound. after 5 consecutive days of daily intramuscular injection of hydrochloric acid gentamicin (0.5mg/kg) 1 second, to prevent infection. 1.4 Preparation of the tissue after 4 weeks, 12 weeks, 20 weeks, two animals in each group were sacrificed immediately taken with at least 1.0 cm area around the repair of composite tissue. Set the composite tissue in 10% neutral formalin in 24h