Hypericin with chronic ocular hypertension in rabbit retinal ganglion cells in histological observation of protective effect of.docVIP

 PAGE \* MERGEFORMAT 19 Hypericin with chronic ocular hypertension in rabbit retinal ganglion cells in histological observation of protective effect of 【Abstract】 Objective: To explore the hypericin with chronic ocular hypertension in rabbit retinal ganglion cells. Methods: 20 adult rabbits after injection of α-chymotrypsin-room establishment of rabbit model of chronic ocular hypertension. Modeling the success of rabbit eyes in the 10d, respectively, after intravitreal injection of hypericin 0.1mL or saline 0.1mL, 1 time / wk, continuous 2wk. The other four normal rabbit to do with the blank control. Last light microscope electron microscopy of retinal ganglion cells and retinal structural changes in the average thickness of the inner changes. Results: The saline control group, reduce the number of ganglion cells, and some serious degeneration, chromatin margination, mitochondria, endoplasmic reticulum and other organelles severe swelling, the average thickness of the inner retinal thinning. Hypericin ganglion cells in the treatment group compared with saline control group morphology minor injury, a slight reduction in the number of ganglion cells, some variability, chromatin margination, mitochondria, endoplasmic reticulum swelling of the lighter. The average thickness of the inner retina with mild thinning, compared with the saline control group, significant difference (P lt;0.01). Conclusion: Hypericin as a specific protein kinase C inhibitor, for chronic ocular hypertension in rabbit retinal ganglion cells under a protective effect. Keywords: hypericin with chronic ocular hypertension neuroprotection of retinal ganglion cells in rabbit The histology observation on the protective effect of hypericin on retinal ganglion cell in chronic ocular hypertension rabbits Abstract AIM: To explore the effect of hypericin on retinal ganglion cell in chronic ocular hypertension rabbits. METHODS: Twenty rabbits were used to build chronic ocula