Hypoxia inducible factor-1α and cyclin E expression in osteosarcoma and its prognostic significance.docVIP

 PAGE \* MERGEFORMAT 14 Hypoxia inducible factor-1α and cyclin E expression in osteosarcoma and its prognostic significance Of: Yin Lei, Ru Jiang Ying, Hu Yuhua, [Abstract] [Objective] To investigate the hypoxia inducible factor -1 @ (HIF-1 @ and cyclin E (cyclinE protein expression in osteosarcoma and biological characteristics and prognostic significance. [Methods] Immunohistochemistry SP method detected 36 cases of osteosarcoma HIF-1 @ and cyclinE expression, and analysis with clinicopathological parameters and prognosis. [Results] (1) HIF-1 @, cyclinE protein in osteosarcoma, the positive rate and average positive labeling index was [61.6% (22/36, (19.64 + -8.78,55.6% (20/36, (19.20 + -9.27], (2HIF-1 @ and consistent cyclinE protein was found 65.8% and a positive correlation between the expression (r = 0.7435, P lt;0.05, (3HIF-1 @, cyclinE protein expression and differentiation of osteosarcoma cells is closely related (P lt;0.01, (4) cases with metastasis HIF-1 @ expression intensity was higher than patients without metastasis (P lt;0.01, (5 Univariate and multivariate survival analysis showed that HIF-1 @, cyclinE high expression of the poor prognosis of patients (P lt;0.05. [Conclusion] HIF-1 @, cyclinE high expression may be involved in malignant progression of osteosarcoma, both on the evaluation of the joint detection of the prognosis of osteosarcoma patients have a certain value. [Keywords:] osteosarcoma, hypoxia inducible factor -1 @, cyclin E, the prognosis Abstract: [Objective] To investigate the expressions of HIF-1 @ and cyclinE in osteosarcoma and their relationships with biological characteristics and prognostic value. [Method] The expressions of HIF-1 @ and cyclinE were examined by SP Immunohistochemical staining in 36 osteosarcoma tissues . The profile was correlated with clinicopathologic parameters and prognosis. [Result] (1) The positive rate and average value of positive label index of HIF-1 @ and cyclinE was [61.6% (22/36, (19.6