Hypoxia inducible factor1 and the status of liver cancer.docVIP

 PAGE \* MERGEFORMAT 16 Hypoxia inducible factor1 and the status of liver cancer [Abstract] Hypoxia inducible factor 1 (HIF 1) is composed of two subunits of the heterodimer protein, the activity is mainly to regulate the stability of a subunit. It is activated in hypoxic conditions , specifically with the target gene hypoxic response element binding, and induction of target gene transcription, increased tumor cell hypoxia adaptation, which will help its growth, proliferation and metastasis. The mechanisms include the promotion of cancer stem cell differentiation, regulation of tumor cells metabolism, promote tumor angiogenesis, tumor cell apoptosis. In recent years, many on liver cancer and liver cancer cells with HIF 1 study reviewed in this paper with liver cancer, development and treatment of the status quo. [Keywords:] Hypoxia inducible factor 1; liver cancer; liver cells; review literature Oxygen is the body’s metabolism and an essential element of survival is a basic pre-cellular life activities. Solid tumor growth to a certain extent, the tumor of oxygen and nutrient consumption over supply, rendering the tumor microenvironment can lead to hypoxia, low-sugar and Low Acid [1], and the tumor’s rapid cell division and abnormal vascular structures resulting in severe oxygen deficiency (hypoxia) parts of tumor cells induced by hypoxia inducible factor (HIFs), HIF now with liver cancer, liver cancer Cell Research is reviewed below. 1 HIF 1.1 Structure HIF 1 is Semenza et al [2] discovered in 1992, they hypoxia in hepatocellular carcinoma cell line Hep 3B cells found in extracts of a protein can be specifically combined with the erythropoietin (EPO) Enhanced oligonucleotide gene sequence, named HIF 1. by purification found in two subunits of the heterodimer, one of a 120kD subunit and a B-subunit is 91/93/94kD , both of which are eukaryotic transcription factors, bHLH (basic helix loop helix) PAS (PER, ARNT, SIM) protein family members. a and