Hypoxia-reoxygenation signal transduction mechanism of renal injury in Progress.docVIP

 PAGE \* MERGEFORMAT 20 Hypoxia-reoxygenation signal transduction mechanism of renal injury in Progress Keywords: Hypoxia-reoxygenation; kidney damage; signal transduction Hypoxic-ischemic renal injury in neonatal asphyxia, pneumonia, shock and renal transplant, kidney incision of common clinical problems such as serious may develop multiple organ dysfunction syndrome or even death. Nuclear factor-κB (nuclear factor  kappa B, NF  κB) involved in a variety of cytokines and inflammatory mediators in gene transcription regulation, regulation of the inflammatory response networks play an important role. 1 Rel / NF  κB signal transduction pathway 1.1 Rel / NF  κB family composition and function of NF  κB is a Rel protein family members, in almost all cells, is currently in mammalian cells easy to find NF  κB Rel family of five members: RelA, NF  κB1, NF  κB2, RelB, and C  Rel. Each member of a family of N  end of the subunit has a total of about 300 amino acid residues of the Rel homology domain (RHD), is mediated by NF  κB-DNA binding are necessary, but also contains a nuclear localization sequence (NLS ), is responsible for activation of NF  κB into the nucleus to play biological functions. Typical NF  κB is composed of subunits p50 and p65 heterodimers, in almost all eukaryotic cells. NF  κB inhibitory protein (inhibitor κB, IκB) family, including IκB  α, β, γ, δ, ε, and Bcl  3. IκB has the following features: ① block NF  κB-DNA binding; ② through NF  κB subunit RHD on the coupling, covering NSL, it can not be the nuclear translocation; ③ to NF  κB-DNA complex formation body dissociation, inhibiting gene transcription. 1.2 NF  κB activation and regulation Resting state, NF  κB and its inhibitory protein IκB and to a combination of non-activated form exists in the cytoplasm. IκB inhibitory protein mainly for the activation of NF  κB disincentive. IκB with ankyrin repeats of t