Inflammatory cytokines and Heart Failure Research.docVIP

 PAGE \* MERGEFORMAT 18 Inflammatory cytokines and Heart Failure Research [Keywords:] inflammation; cell factor; heart failure; myocardial contractility; ventricular remodeling Cytokines are cell subjected to internal and external environmental changes stimulated the secretion of a functional protein molecules, members of his family, including tumor necrosis factor (TNF), interleukin (IL), interferon, colony stimulating factors, growth factors, chemotactic factor family and so on. cytokines mainly involved in activation of signal transduction pathways, increasing the level of intracellular messenger, activating transcription factor, inducing genes encoding other physiological and pathological processes. Among the many inflammatory cytokines, play a major role in the TNF @, IL 1, IL 6, TGF , IL 10. inflammatory cytokine cascade for heart failure, development has an important role. research shows that it can reduce cardiac contractility and cardiac output, and trigger spontaneous dysfunction, insulin resistance, endothelial damage and hypercoagulability, etc. (1). cytokines in heart failure increased, the level is to determine the severity of heart failure and prognosis of anti-inflammatory treatment can reduce the incidence of heart failure patients at high risk (2, 3). 1 TNF @ TNF @ mainly by the LPS (lipopolysaccharide, LPS) such as activated monocytes / macrophages, is composed of 157 amino acid peptide, a molecular weight of 17 kD.TNF receptor (TNFR), there are two, low- affinity receptor TNFR1 (molecular weight 55 kD) and high-affinity receptor TNFR2 (MW 75 kD). study confirmed, TNF @ through TNFR1 in the pathogenesis of heart failure, and protect the heart from the role of TNFR2 (4). TNFR cells After the outer part by a soluble TNF protease receptor editing (sTNFR), into the blood and urine, rapid and TNF @ combine to form a trimer, on the one hand to prevent TNF @ TNFR binding to sites on the cell membrane play a role in the cell buffer toxici