Matrix metalloproteinases and their inhibitors and eye diseases.doc

 PAGE \* MERGEFORMAT 16 Matrix metalloproteinases and their inhibitors and eye diseases [Keywords:] matrix metalloproteinases and their inhibitors eye diseases Matrix metalloproteinases (matrix metalloproteinases, MMPs) are a class of metal dependent hydrolase family, is the extracellular matrix (extracelluarmatrix, ECM) degradation of the major media, whose main function is to degrade the extracellular matrix in cell migration, tissue remodeling and repair and so play a role in the pathophysiological process. MMPs proteolytic activity depends mainly on its inhibitor (tissueinhibitor ofMMPs, TIMPs) to adjust the balance between. Recent studies show that the imbalance between the regulation of eye tissues can lead to a series of pathophysiological changes , and many eye diseases, MMPs and TIMPs in this paper the role of eye diseases and clinical significance to be reviewed. 1 MMPs and TIMPs family, classification, structure, physical and chemical properties 1.1 MMPs and TIMPs and classification of family Since the 20th century, since the early 80s, people MMPs enzymes studies have found that at least 20 kinds of MMPs, in accordance with the basic structure of these enzymes and the main role of the different substrate is divided into five categories, the first category collagenase: Inter- collagenase (MMP-1), polymorphonuclear collagenase (MMP-8), collagenase 3,4 (MMP-13, MMP-18), the main substrate for the fibrous collagen, gelatin second enzymes: gelatinase-A (MMP-2), gelatinase-B (MMP-9), its main substrate is gelatin, , V collagen and fibronectin, etc. The third category of interstitial soluble factors: inter- quality of dissolved elements 1,2,3 (MMP-3, MMP-10, MMP-11) and matrilysin (MMP-7), mainly hydrolyzed laminin, non-fibrous collagen and fibronectin, the fourth film metal protease: membrane-type metalloproteinase -1,2,3,4 (MT-MMP1, 2,3,4), the main substrate for the hydrolysis of precursor MMP-2, collagen and gelatin, other types: MMP-12,