Mechanical ventilation on inflammatory response in acute lung injury.docVIP

 PAGE \* MERGEFORMAT 14 Mechanical ventilation on inflammatory response in acute lung injury Of: Ye Zhenglong Xuqiao Lian Li Shirong Zouhui Qiu Hai-bo [Abstract] Objective: To evaluate the different tidal volumes on the acute lung injury (ALI inflammatory response in rats. METHODS: 30 male SD rats were randomly divided into control group, ALI group, low tidal volume (LV group, the traditional tidal volume ( NV group and the high tide volume (HV group 5 group. mechanical ventilation 4 h, the lung tissue biopsy Smith score, lung water content (W / D measurement, lung permeability (LPI measurement (measured by radioimmunoassay in plasma and bronchoalveolar lavage 125I albumin solution were calculated the ratio between the two, ELISA determination of BALF TNF @, IL 10 content. Results: Smith score, W / DLV group than in ALI, NV, HV was significantly reduced. lavage fluid in TNF @, IL 10 content LV group than in the NV, HV was significantly reduced. Conclusions: Low tidal volume ventilation can reduce lung inflammation, thereby reducing lung tissue injury, has a protective effect on ALI. [Keywords:] acute lung inflammation in rats with mechanical ventilation Abstract: Objective To evaluate the influence of ventilation with different tidal volume on inflammatory response in rats with acute lung injury (ALI). Methods 30 male SD rats were randomly divided into five groups: normal group, ALI group, low tidal volume (LV) group, traditional tidal volume (NV) group, high tidal volume (HV) group.After 4 hours of mechanical ventilation, lung injury was evaluated by Smith lung injury score, lung water content (wet / dry, W / D) and lung permeability index (LPI), tumor necrosis factor @ (TNF @) and interleukin 10 (IL 10) levels in bronchoalveolar lavage fluid (BALF) were measured by ELISA. Results Smith lung injury score and W / D in LV group were significantly lower than those in NV group and HV group, and Smith lung injury score, W / D, and LPI in HV group was