Melanocytes in the skin reservoir areas such as research.doc

 PAGE \* MERGEFORMAT 26 Melanocytes in the skin reservoir areas such as research Abstract: The melanocytes produce melanin, the formation of the normal skin color. However, vitiligo lesional melanocytes significantly reduced or even disappear. Therefore, if the partial resumption of pigmented skin lesions of vitiligo. Melanocytes come from, it is people are concerned about hot spots. Recently it has been pointed out that the existence of melanocytes in human skin cells, storage, on right to play an important role in the treatment of vitiligo. Now on the skin melanocyte reservoir and its related research, to make a brief introduction. Melanocytes (mC) originated in the neural crest, in the embryonic development of the first seven weeks into the epidermis. Melanin produced by the mC, through the dendrites enter the surrounding keratinocytes (kC), the development of skin pigment and to protect the body from ultraviolet radiation (uVR) injury [1]. Vitiligo is a kind of unknown cause significant local skin pigment decreased or disappeared in skin diseases, vitiligo skin has been confirmed that mC significantly reduced or even disappear, while the mC of the disease occurrence and pigment recovery play an important role [2,3]. First, human skin melanocytes in vitiligo lesional distribution and changes in MC exist in the epidermis of human skin, matrix and outer root sheath. ronald and others found in three different subpopulations of mC: ① epidermal melanin within the moderate-based, multi-dendrites mC; ② hair follicles within the small, bipolar, non-melanin mC; ③ hair follicle melanin within the large height of the mC . The first two in fostering the proliferation of good, while the latter does not proliferating; of these ② ① lower than the degree of differentiation, mature melanosome antigens less [4]. Vitiligo lesions histological changes, mainly two aspects, first mC epidermal basal layer damage, and then the