Mica particles on acetic acid-induced colitis in rats inflammation and repair response in.doc

 PAGE \* MERGEFORMAT 9 Mica particles on acetic acid-induced colitis in rats inflammation and repair response in Author: Ying-Ying Yang Shao-Ping Qin Dan forever National Ren Jianxin Han Abstract [Objective] To investigate the mica particles (referred to as mica) on acetic acid-induced colitis in rats and its possible mechanism of therapeutic effect; [Methods] After modeling, mica suspension enema once a day to observe the first 3 after modeling days and 14 days of colonic mucosal injury and the light microscope performance, serum and colon tissues of EGF, TNFa content; [Results] Mica 3 days and 14 days of the acetic acid-induced colitis rat colon mucosal damage and the general concept of both to improve the role of histology, while the rats serum and colon tissue repair factor relative increase in EGF concentration, caused by inflammatory cytokines TNFa levels decrease. [Conclusion] Mica acetic acid-induced colitis in rats may be related to the therapeutic effect of a corresponding increase in fixed factor EGF levels and lower levels of inflammatory factors related to TNFa. Keywords: colitis; mica particles acetic acid; epidermal growth factor; tumor necrosis factor Abstract: [Objective] To study Mica granule’s treatment on rats’ ethanoic acid colitis and the possible mechanism. [Method] After modelling, apply Mica suspending liquid for enema once a day, observe demonstration under microscope and enteric mucosa injury at 3th day and 14th day, measure EGF and TNFa in serum and colon tissue. [Result] The Mica had improvements on colon mucosa injury and tissue of rats with colitis generally, meanwhile it could comparatively add EGF  the repair factor in colon and serum of rats, also decrease inflammatory factor TNFa. [Conclusion] Mica’s treating rats’ ethanoic acid colitis may be related with its comparatively raising repair factor EGF and reducing TNFa. Keywords:: colitis; ethanoic acid of Mica Granules; epidermis growth