Micro-cut to help each other to make technical-assisted extraction technology of andrographolide.doc

 PAGE \* MERGEFORMAT 12 Micro-cut to help each other to make technical-assisted extraction technology of andrographolide Author: Song Chunna Wang Yang Li-Ji Jin Xu Yongping [Abstract] Objective To study the interaction of micro-cut technical assistance to help extract the optimum andrographolide. Methods andrographolide extraction rate of the indexes, by a single factor and orthogonal micro-cutting to help study the interaction of technology-assisted extraction of andrographolide main factors to determine the optimum process conditions; using high performance liquid chromatography Andrographolide ester content. Results optimum conditions: Na2CO3 additive amount of 3% (W / W), grinding time was 45 min (material particle size D95 ≤ 44 μ m), water as solvent, solid-liquid ratio of 1:60 (g: ml) . The process conditions, andrographolide heat reflux extraction rate increased 23.2%. Conclusion micro-cutting to help each other to make technical-assisted extraction with high extraction rate, time is short, no heat, ethanol, etc. with less features, the extraction of andrographolide an effective way. [Keywords:] micro-cutting to help each other to make technical-assisted extraction; andrographolide; andrographolide; orthogonal experiment Andrographolide (Andrographolide) for the Acanthaceae plant Andrographis Andrographis paniculata (Burm.f.) Ness of the main active ingredient, modern pharmacological studies have shown that its has anti-inflammatory, anti-virus, anti-tumor, enhance immunity, nourish the liver and gallbladder, anti - reproductive and other pharmacological effects. Andrographolide extraction methods of percolation method [1], impregnation [2], acidic water method [3], alkaline method [4] and ultrasonic extraction method, etc. [5], there is a long cycle, a large amount of solvent disadvantages. Micro-cutting to help each other to make technology, is the use of high-intensity grinding produced by mechanical and chemical effects [6], the plant is co-gri