New hydrophilic coating on rabbit coronary stent thrombosis of.doc

 PAGE \* MERGEFORMAT 13 New hydrophilic coating on rabbit coronary stent thrombosis of Study: Zhao Jiayi Zhao Lei Zhang Shu-Mei Zhang Jifeng base Chang [Abstract] purposes of medical 316L stainless steel bare metal stents made of silane treatment of different degrees of surface modification of hydrophilic coronary stent, and test their blood compatibility. Methods 25 experimental rabbits were randomly divided into 3 SH trimethoxysilane hydrophilic coated stent group (A group), 3 (2-aminoethyl) aminopropyl trimethoxysilane hydrophilic coated stent group (B group), bare stent group (C group ), paclitaxel drug-eluting stent group (D group), no stents negative control group (E group), n = 5. the variety of stents were implanted into the appropriate A, B, C, D group of rabbit abdominal aorta , in the first week of blood testing 1,2,4 rabbit serum CRP, sVCAM 1, MMP 9 levels; the first 4 weeks, abdominal aortic intravascular ultrasound (IVUS) examination, to observe the extent of stent endothelialization and surface thrombosis. results of the first week of stent groups 1,2,4 rabbit serum CRP, sVCAM 1, MMP 9 levels were significantly higher than the E group (P lt;0.05); serum CRP levels at 4 weeks A group than in the B, C, D was significantly higher (P lt;0.05), group B 4 weeks C, D groups were significantly different (P lt;0.05); serum sVCAM 1 level of A, B, C, D, after stent implantation in each group 2, 4 weeks compared with no significant difference between week 1, B, D group were significantly lower than A weekly group (P lt;0.05), B group 4 weeks compared with the D group were significantly different (P lt;0.05); the serum levels of MMP 9 A, B, C, D group 4 weeks after stent implantation compared with 1,2 weeks were significantly increased (P lt;0.05), C group on 2,4 weeks and no significant difference between group A, the first 4 weeks A group was significantly higher than that of B group, D group was significantly lower than B group (P lt;0.05); the first