Ning of asthmatic guinea pigs on asthma leukotriene B4 soluble intercellular adhesion molecule -1 Content.docVIP

 PAGE \* MERGEFORMAT 24 Ning of asthmatic guinea pigs on asthma leukotriene B4 soluble intercellular adhesion molecule -1 Content [Abstract] Objective To observe the anti-asthmatic guinea pig asthma leukotriene Ning B4 (LTB4), soluble intercellular adhesion molecule -1 (sICAM-1) content, explore the biological mechanisms related to asthma. Methods eggs Copy sensitized guinea pig asthma model eggs to observe the changes in latent period of asthma in guinea pigs, using enzyme-linked immunosorbent assay reaction technique (ELISA) determination of LTB4 in the guinea pig serum and bronchoalveolar lavage fluid bronchitis (BALF) sICAM-1 in content. Results asthma Ning administration, the guinea pigs was significantly prolonged latent period of asthma, asthma Ning guinea pigs significantly reduced LTB4 in serum and bronchoalveolar lavage fluid (BALF), sICAM-1 levels, with the asthma model group comparison, P lt;0.05 or P lt;0.01. Conclusion asthma rather obvious asthma, its mechanism and reduced serum LTB4 guinea pigs and BALF sICAM-1 in the content. [Keywords:] Ning asthma, asthma, soluble intercellular adhesion molecule -1, leukotriene B4 Abstract: Objective To observe the effect of Pingchuanning on the levels of LTB4 and sICAM-1 of guinea pigs with asthma. Methods The model guinea pigs of asthma were sensitized with ovalbumin (OVA), the changes of the delitescence of asthma was observed. The levels of LTB4 in serum and sICAM-1 in bronchoalveolar lavage fluid (BALF) were also observed by means of enzyme-linked immunosorbent (ELISA). Result Comparing with the model group, the delitescence of asthma was obviously prolonged in guinea pigs treated by Pingchuanning . The levels of LTB4 and sICAM-1 of guinea pigs with asthma treated by Pingchuanning were significantly lowered (P lt;0.01 or P lt;0.05). Conclusion Pingchuanning has obviously effect of treating asthma and its mechanism is probably due to the decrease of LTB4 and sICAM-1. Keywords:: Pingchuanning,