Ningxia Hui population CYP2D6 10 allele and genotype frequencies.doc

 PAGE \* MERGEFORMAT 9 Ningxia Hui population CYP2D6 10 allele and genotype frequencies Of: Li Zongji, Wang Jian, Wang Huicheng, Ge Lijun [Abstract] Objective Ningxia Hui ethnic population CYP2D6 * 10 allele and genotype frequencies for the clinical use of CYP2D6 substrate to provide evidence of drug. Methods allele specific amplification (ASA-PCR technology, analysis of 180 patients with medical Hui who CYP2D6 genotype. Results CYP2D6 * 10 gene point mutation results in the frequency of homozygous wild-type 32.3%, 38.3% heterozygous frequency, mutation frequency was 29.4% homozygous, mutant allele frequency was 48.6%. Conclusion The population of Ningxia Hui CYP2D6 * 10 allele and other ethnic groups have some differences at home and abroad, in the clinical application of drug metabolism by CYP2D6 should be considered when differences in metabolic rate between individuals, to ensure safe and effective medication. [Keywords:] CYP2D6 * 10, gene, polymorphism, Hui Abstract: Objective To investigate the allele and genotype frequences of CYP2D6 * 10 in Ningxia Hui population. Methods 180 Ningxia Hui blood samples were collected. The ASA PCR was performed and the PCR products were genotyped.Results The mutant allele frequences were 48.6%. Conclusion CYP2D6 * 10 allele frequences between Ningxia hui ethnicity and other populations was significantly different. Keywords:: CYP2D6 * 10, gene, polymorphism, Hui ethnicity Cytochrome P450 2D6 (CYP2D6), also known as sulfuric acid debrisoquine hydroxylase, is widely studied in recent years, a liver microsomal enzyme polymorphism in oxidative metabolism of drugs, the enzyme involved in 30 kinds of drugs commonly used in clinical Hydroxylation such as anti-depression drugs, anti-arrhythmic drugs, 2 blockers, etc. [1-3]. because at least 50 multiple CYP2D6 mutations and 73 alleles, so the activity of enzymes are highly polymorphic [4 - 5]. CYP2D6 gene has obvious racial differences. We at 1 July 2007 between t