NTproBNP in elderly heart failure and the significance of different doses of angiotensinreceptor antagonist Intervention.doc

 PAGE \* MERGEFORMAT 17 NTproBNP in elderly heart failure and the significance of different doses of angiotensinreceptor antagonist Intervention [Abstract] Objective To study the chronic heart failure (CHF plasma N-B-type natriuretic peptide (NT proBNP levels and severity of heart failure, plasma endothelin (ET 1 correlation between the concentration of different dosages by angiotensin antagonist (ARB for CHF patients with NT proBNP and ET 1. Methods 70 patients with stable clinical symptoms in elderly CHF patients receiving conventional therapy were randomly divided into small dose (valsartan 40 ~ 80 mg / d and higher dose group (120 ~ 160 mg / d, for 12 weeks, patients were measured before and after treatment of the index [plasma ET 1, NT proBNP concentrations, left ventricular end diastolic diameter (LVEDd, left ventricular ejection fraction (LVEF, heart rate, blood pressure], observed changes in the indicators before and after treatment and the differences between the groups. while 30 cases were age-matched healthy controls were determined based on plasma ET 1, NT proBNP concentrations. Results elderly CHF patients with concentrations of plasma NT proBNP New York Heart Association functional class (NYHA increased higher and LVEF was significantly negatively correlated (r =- 0.328, P = 0.013, NT proBNP and LVEDd and plasma ET 1 was a significant positive correlation (r = 0.431, P = 0.016, r = 0.412, P = 0.005, high dose group than in the low dose group more significantly reduce plasma NT proBNP, ET 1 concentration, the larger dose group were treated with low-dose administration of gradually increasing doses of the way, safe and well tolerated good. Conclusions CHF plasma NT proBNP concentrations are closely related with the severity of heart failure, and NT proBNP and plasma concentrations of ET 1 was a positive correlation. plasma NT proBNP concentration of heart failure diagnosis, treatment and prognosis of good indicator. in the elderly CHF patients w