On recombinant human erythropoietin on myocardial apoptosis in severe burns of.docVIP

 PAGE \* MERGEFORMAT 9 On recombinant human erythropoietin on myocardial apoptosis in severe burns of OF: Ms Liu Yi Jiang Cheng Sun Mengkui weeks dry [Abstract] Objective: To study the recombinant human erythropoietin on Ⅲ ° burn myocardial apoptosis in rats. Methods: Ⅲ ° burn model, rats were randomly divided into burn group and control group, EPO treatment group. Per kg body weight in rats after scald burn area of #8203;#8203;4 mL of 1% saline intraperitoneally, and the animals were sacrificed 18 h after injury. HE staining and SP immunohistochemical staining of myocardial tissue structure changes and bcl 2 gene expression. Results: EPO treatment group, myocardial apoptotic index was significantly lower than the burn group (P lt;0.01), bcl 2 protein expression was also significantly higher than the burn group (P lt;0.01). Conclusion: EPO on myocardial apoptosis after burn better inhibition, which may be EPO regulation of apoptosis related genes bcl 2 expression. [Keywords:] erythropoietin; burn; apoptosis; myocardial In recent years, studies have shown that severe burns can cause apoptosis in some tissues and organs, and apoptosis leading to cardiac dysfunction after burn is an important factor, the result may be related to oxygen free radicals and Ca2 + balance and other related disorders [1] But the detailed mechanism is unclear. EPO (erythropoietin, EPO) is an important hematopoietic growth factor, is an important regulator of erythropoiesis agents [2]. Recent studies found that, EPO on isolated adult rat cardiomyocytes and the whole myocardial ischemia / reperfusion injury have shown protective effects, can apoptosis of myocardial cells in vitro by 15% to 30% [3,4]. inhibiting myocardial apoptosis after burns is an effective protection of myocardial cells way. EPO after another reported that although the treatment of cardiovascular diseases, but about EPO on myocardial apoptosis after burn protective effect has not been reported [5]. This