On the compound in ovariectomized rats in Kidney effects of osteoporosis.docVIP

 PAGE \* MERGEFORMAT 11 On the compound in ovariectomized rats in Kidney effects of osteoporosis Of: the Water bamboo, Huo Yaping, Guan Kun Ping, Tian Feng, Zhang Jianyu, Zhang Luo [Abstract] Objective To observe the effects in Kidney to the role of osteoporosis in rats and from the molecular level to explore its mechanism. Methods established by removal of rat ovaries model of postmenopausal osteoporosis. Ovariectomized after 1 week, with the intragastric method to the service Kun Capsules 10 weeks to nylestriol saline as control group were observed morphological changes in bone mineral density and bone, and RIA used to detect the bone tissue IL-1β, IL-6 and TNF-@ in the content. Results of Chinese medicine group was significantly higher than BMD in the OVX group (P lt;0.01), bone morphology has also improved significantly. The bone tissue of IL-1β, IL-6 and TNF-@ were significantly lower than in the OVX group (P lt;0.05). JOURNAL OF TRADITIONAL CHINESE can better prevent ovariectomy induced osteoporosis, its mechanism might be able to effectively reduce the ovariectomized rat bone tissue microenvironment cytokine IL-1β, IL-6 and TNF-@ levels and decrease bone loss. [Keywords:] Osteoporosis, interleukin -1, interleukin -6, tumor necrosis factor - @, animal models, kidney medicine Abstract: Objective To observe the influence of kidney invigoration drug on of osteoporosis ovariectomy rats and study its mechanism. Methods Adult ovariectomized rats were used in this study as the model of postmenopausal osteoporosis. After being fed with the drug of kidney invigoration for 10 weeks, the general BMD of rats, the level of IL-1β, IL-6 and TNF-@ in bone were tested. And the histological changes of bone were observed. Results Compared with the model, the general BMD in treated groups increased significantly (P lt;0.01) while the level of IL-1β, IL-6 and TNF-@ in bone decreased significantly (P lt;0.05). The level of IL-1β, IL-6 and TNF-@ in bone of ovariect