Panax quinquefolium saponins on mice peritoneal macrophage immune function of.docVIP

 PAGE \* MERGEFORMAT 7 Panax quinquefolium saponins on mice peritoneal macrophage immune function of Authors: Ding Tao, Shang Zhi, Wen Fu-Chun, Zhang Wei, Zhang Dianwen, Jifeng Lan, XU Hui-bo [Abstract] Objective: To observe the Panax quinquefolium saponins on activated mouse peritoneal macrophages in cell metabolism and secretion of nitric oxide (NO), interleukin-1 (IL  1) activity. Methods: Different concentrations of ginseng leaf saponins join the in vitro cultured mouse peritoneal macrophages to NO detection kit NO content of culture supernatants to MTT (MTT) colorimetric assay macrophage metabolism and production of IL  1 activity. Results: Panax quinquefolium saponins can promote the metabolism of mouse peritoneal macrophages and produce NO, and NO generation in a dose-dependent relationship between the activity of IL  1 had no significant effect. Conclusion: Panax quinquefolium saponins can enhance the activity of mouse peritoneal macrophages may be Panax quinquefolium saponins regulate the immune function of an important way. [Keywords:] Panax quinquefolium saponins mouse peritoneal macrophages of nitric oxide interleukin-1 Panax ginseng for five species, sweet, slightly bitter flavor and a cool nature, with nourishing strong, nourishing Sheng Jin, Ning God puzzle and so on. Modern pharmacological studies have shown that Panax quinquefolium saponins have anti-virus, anti-mutagenic, anti-arrhythmia, lower blood lipids, such as the role of anti-lipid peroxidation [1]. Panax quinquefolium saponins for further study of the immune regulatory role, this study observed Panax quinquefolium saponins on in vitro metabolism of mouse peritoneal macrophages and generation of NO levels, IL  1 activity. An experimental material 1.1 Animals Balb / c mice, 6-7 weeks old, weighing 20-22g, Department of Basic Medicine, Jilin University Experimental Animal Center. 1.2 Drugs and reagents Panax quinquefolium saponins provided by the Jilin Provincial Academy of