Patients with heart failure in the role of brain natriuretic peptide and different doses of angiotensin-converting enzyme inhibitors to interfere.docVIP

 PAGE \* MERGEFORMAT 19 Patients with heart failure in the role of brain natriuretic peptide and different doses of angiotensin-converting enzyme inhibitors to interfere Author: Song Haoming Jia Deng Bing Luo [Abstract] Objective To study the chronic heart failure (CHF) in patients with plasma brain natriuretic peptide (BNP) concentration and the severity of heart failure, plasma norepinephrine (NE) concentrations of the correlation between different doses of angiotensin-converting enzyme inhibitors (ACEI) on the CHF patients with BNP and NE of the impact and feasibility of large doses of ACEI and security. Methods 66 patients with clinical symptoms of stable CHF patients on the basis of treatment were randomly divided into smaller doses on the basis of group (perindopril 2 ~ 4mg / d), higher dose group (8 ~ 10mg / d), the treatment for 12 weeks , measured before and after treatment in patients with two groups of indicators (plasma NE, BNP concentration, left ventricular end-diastolic diameter (LVEDd), left ventricular ejection fraction (LVEF), heart rate, blood pressure), observed changes in the indicators before and after treatment and group difference. And chose 30 cases of age-matched normal controls were measured basic plasma NE, BNP concentration. The results of plasma BNP concentration in patients with CHF with New York Heart Association functional class (NYHA) classification increased rise, and LVEF was significantly negatively correlated (r =- 0.327, P = 0.012); BNP and plasma NE with LVEDd showed a significant positive correlation (r = 0.42, P = 0.015; r = 0.402, P = 0.002). Higher dose group is relatively small dose group more significantly decreased plasma BNP, NE concentration. Higher-dose group were treated with low-dose administration of gradually increasing doses of ways, and well tolerated. Conclusions CHF plasma BNP concentration is closely related with the severity of heart failure, but BNP and plasma NE were positively correlated. Plasma B