Pharmacological Effect of PSK.doc

 PAGE \* MERGEFORMAT 8 Pharmacological Effect of PSK Authors: ZHANG, XU Hui-bo, DING Tao, Wen Fu-Chun, Zhang Dianwen, Xiao-Bo Sun [Keywords:] PSK; immune-enhancing effect; anti-tumor effect Versicolor [Trametes versiolor (L.: Fr.) Pilá t], belong to Basidiomycotina (Basidiomycotina), Polyporaceae (Polyporales), Trametes (Trametes). Versicolor of micro-Gan, cold, can heat, anti-inflammatory, with righting strengthen our foundation, the effect of replenishing qi fine. PSK from the fruiting bodies of Coriolus versicolor polysaccharide extracted (CVPS), from the submerged culture mycelia of Coriolus versicolor was isolated to a binding protein polysaccharide (PSK), from another culture COV  1 strain obtained by mycelium glycoprotein mixture (PSP) [1], data shows that is a variety of biologically active polysaccharide, are the following studies. An immune-enhancing role of Immune enhancement is the most important pharmacological activity of Coriolus versicolor, by intraperitoneal injection of PSK can be strong mouse peritoneal macrophages GST  P mRNA expression. Induced mouse peritoneal macrophage SeGPx activity was enhanced; PSK enhanced IFN  γ on the inhibition of macrophage LDL; while PSK can enhance the IFN  γ secreting cells induced by NO, reduced N  Arg on cell secretion NO inhibition [2]. Intraperitoneal injection of CVPS can improve the mouse peritoneal macrophage cell culture supernatants of M  CSF activity, and to macrophages M  CSF mRNA were increased [3]. CVPS in vitro administration, can promote the mouse T, B lymphocyte proliferation, phagocytosis of neutral red markedly enhanced the capacity of TNF, significantly increased the activity of cytokines IL1 [4], intraperitoneal injection of PSK injection 10mg/kg, pairs of 60Co-irradiated BALB / C mice and the spleen index of lysozyme content in a significant recovery effect, CVPS immune function of red blood cells to radiation damage has obvious protective effect on red cell immune f