Phyllanthus extract an effective part of the overall long-term toxicity tests in rats.doc

 PAGE \* MERGEFORMAT 14 Phyllanthus extract an effective part of the overall long-term toxicity tests in rats Author: Wen Zhijian PENG Ling Yang Aspen Zhao Xue-Ning Zhou Yonglu Mirren 【Abstract】 Objective To observe the parts of Phyllanthus effective long-term toxicity of total extract of the body may cause toxic reactions, in order to provide a safe basis for the clinical. Methods from Phyllanthus extract an effective part of a total 1 280,640,320 mg / kg gavage 1 day consecutive administration of 180 d and 30 d after stopping the growth observed in rats, as well as routine hematology, blood biochemistry indicators, and major organs weight ratio, the main pathological organs, electrocardiogram impact. The results on rat growth and development, routine hematology, blood biochemical parameters were within normal range: The main organ body weight ratio, the main pathological organs, electrocardiogram changes in toxicity were not there. Conclusion toxicity in rats 180 d long experiment results showed that Phyllanthus extract is an effective part of the overall low toxicity. Keywords: total extract of Phyllanthus urinaria; long-term toxicity Abstract: ObjectiveTo observe the chronic toxicity of TEY in rats. MethodsRats of three experimental groups were administrated. TEY at dose of 1280,640 and 320 mg / kg * d-1, respectively, 6 days per week for 6 months. Rats of control group were given distilled water with the same volume. Growth of rats were observed. Indexes of hematology and blood biochemistry were measured. Ratio of viscera to body were measured and the major organs were examined by the pathology. All these tests were carried out three and six months after administration and one month after stopping administration. ResultsThe outer appearance and behavior, weights, the indexes of hematology and blood biochemistry were normal. The organ coefficient, the cardiogram, the pathological examination had no significant difference by comp