Pneumonia Research and Development of Animal Models.doc

 PAGE \* MERGEFORMAT 23 Pneumonia Research and Development of Animal Models [Keywords:] status of animal model of pneumonia The current bacterial pneumonia (bacterial pneumonia pathogens, accounting for various types of pneumonia in adults 80%. However, the past 30 to 40 years, due to the constant increase in the rate of bacterial resistance, a large number of extended broad-spectrum antibiotics into the clinic or did not make the death of pneumonia rate continued to drop. There are reports of death of patients hospitalized with pneumonia about 15%. community-acquired pneumonia (CAP) mortality rate of 5% to 10%, while hospital-acquired pneumonia (HAP) of the mortality is as high as 20% to 50% . pneumonia symptoms tend not typical, so-called “severe” pneumonia have occurred, especially in infants and young children, the elderly and immunosuppressed patients with high mortality rate. to improve the level of etiological diagnosis of pneumonia, the establishment of animal models of pneumonia, established diagnostic criteria for pneumonia and pneumonia in the animal model of observation, clinical management of severe pneumonia is urgent and urgent need to address the issue. Domestic and foreign scholars in the last half of the century has established a variety of models of pneumonia, such as the Cartesian model of Pneumocystis carinii pneumonia, chlamydia pneumonia model, E. coli pneumonia model, bacterial bronchial pneumonia models, the model to study the pathogenesis of pneumonia and evaluated the foundation. this reference information, review the literature in recent years, as colleagues to provide more relevant studies on pneumonia model information. A card model of Pneumocystis carinii pneumonia Pneumocystis carinii pneumonia Card (Pneumocystis Carinii Pneumonia, PCP is a serious opportunistic infections, occurs in AIDS patients and other immune deficiencies or immune suppressed patients. Mechanism is based on a variety of reasons immunity, dec