Post-operative thrombosis research.doc

 PAGE \* MERGEFORMAT 18 Post-operative thrombosis research Author: Closed-hung Jie, Ouyang Xiulian, Mi Xian Feng [Keywords:] surgery; thrombosis; Diagnosis Surgery on the body is a kind of trauma, post-operative body of the system will place a series of complex pathophysiology of disease, coagulation and fibrinolytic systems and other systems will similarly change. For the coagulation and fibrinolytic system in which thrombosis plays an important role, if there is hypercoagulable state, can lead to thrombosis. Thrombosis and the high incidence of thromboembolism was 30% to 50% [1], in severe cases can be life-threatening. Coagulation and fibrinolysis system in the current molecular markers in internal medicine to carry out better, such as cardiovascular and cerebrovascular diseases prevention and control work, but in surgical systems, especially surgical departments doing work in this area is relatively small, short shrift. Surgery and thrombosis are closely related to the high-risk patients in the early thrombosis in drug prevention, can significantly reduce thrombosis and embolism treatment are important. By the mechanism of post-operative thrombosis, diagnosis and prevention research are summarized as follows: A mechanism of post-operative thrombosis Surgery-induced thrombosis of the main mechanisms are: vessel wall injury, blood flow increased slow down and blood coagulation. Although the normal hemostatic mechanisms are based on the above three links, but generally mild vascular injury, coagulation and hemostasis can function in the local injury site, while the partial thrombosis usually not life-threatening, but in major surgery of the pathological cases, the body’s hemostatic function may be abnormally high levels, leading to excessive formation of thrombosis, a serious life-threatening. 1.1 The vessel wall injury in surgery, especially major surgery, can directly damage local organizations and the vessel wall, thus trigger thrombosis. Was mainly d