Prognosis of acute lymphoblastic leukemia and its related factors.docVIP

 PAGE \* MERGEFORMAT 31 Prognosis of acute lymphoblastic leukemia and its related factors Authors: ZHANG Wei, Fu Rong, Liu will be, Cheng Yu Qian 【Abstract】 In order to understand the prognosis of acute lymphoblastic leukemia and its related factors, for 1996-2005 in our hospital admitted 53 patients with newly diagnosed acute lymphoblastic leukemia (ALL) patients with analysis of efficacy and prognosis, to understand their remission rate, relapse rate The total survival and event-free survival, and use the same period in case-control method to explore the relationship between different factors and prognosis. The results showed: ALL overall response rate was 67.9%; total recurrence rate was 37.7%, with a median time to relapse after complete remission for 6 months; 18 months, overall survival (OS) was 35.1%, with a median survival time was 4 months ; 18-month event-free survival (EFS) was 14.2%, median event-free survival time of 1 month. EFS in patients with different genders significant difference between; age was independently associated with remission rate factors. When the total number of newly diagnosed white blood cell and hemoglobin levels significantly correlated with OS and EFS, the higher the total number of newly diagnosed when the white blood cells, the higher the risk of death and recurrence; higher hemoglobin levels, the lower the risk of death and recurrence. Induced by absolute neutrophil (ANC) for the OS, independently associated factors, induced ANC higher the lower the risk of death. Infections after chemotherapy in an independent factor for relapse after chemotherapy can affect bleeding OS, while the induction chemotherapy in the high fasting blood glucose were low relative OS. Conclusion: Acute lymphoblastic leukemia relapse rate, as opposed to adults, children, poor prognosis, should be based on individual disease risk groups for treatment, prevention and control infection and bleeding, in order to reduce recurrence and prol