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2017-05-05 发布于浙江
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Proton pump inhibitors side effects and drug interactions.doc

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Proton pump inhibitors side effects and drug interactions

Proton pump inhibitors side effects and drug interactions [Abstract] retrieve a variety of domestic and international public offering of medical journals, Review of proton pump inhibitors, adverse reactions and drug interactions. Reported a variety of adverse reactions related to the growing, and some even fatal, such as anaphylactic shock, rhabdomyolysis, interstitial nephritis leading to renal failure and a narrow therapeutic window due to the impact of some of the risks of drug metabolism lead to the hope that can cause clinical the attention of medical workers. [Keywords:] proton pump inhibitor; adverse reaction; drug-drug interactions Proton pump inhibitors (PPIS) that the H / K ATP inhibitor, blocking the final step in gastric acid secretion is widely used with acid-related diseases. In which omeprazole (OME) 1979 Nian Synthesis, 1989, listing, then continue to develop market of lansoprazole (1994), pantoprazol (1997), rabeprazole, esomeprazole, etc. With PPIS extensive use of a variety of adverse reactions and drug interactions reported also on the rise, are described below. A digestive system adverse reactions 1.1 digestive system adverse events mainly PPIS the most common adverse reactions, mainly with abdominal pain, diarrhea, constipation, nausea, vomiting, etc. The incidence is 1% ~ 4%, generally did not require withdrawal, the lesser of withdrawal symptoms ease after themselves. Occasionally, severe diarrhea leading to dehydration, which require hospitalization. It is noteworthy that the diarrhea caused by lansoprazole is more coverage, mukherjee s [1] reported that a special case, 1 case 49-year-old man due to gastro-esophageal reflux using lansoprazole 30 mg, 1 times / day, After 4 weeks, severe diarrhea, 10 to 15 times a day watery diarrhea, do not take during the other new drugs, the routine examination, colonoscopy was normal, colon biopsy showed acute or chronic inflammation, diagnosed under the microscope colitis with sulfasalazine therapy