Reactive oxygen species and the research progress in potassium channel cochlear.doc

 PAGE \* MERGEFORMAT 25 Reactive oxygen species and the research progress in potassium channel cochlear [Abstract] reactive oxygen species (oxygen free radical theory of aging is one of the main body, reactive oxygen species play a role in the aging process in the attention. This paper, for age-related hearing loss in the pathogenesis of reactive oxygen species with each other potassium channel cochlear Review of the progress of the research. [Keywords:] potassium channel cochlear reactive oxygen species The patch clamp technique and molecular biology advances in experimental methods, after the cochlea potassium channel gene cloning, assembly, mutant, variant expression and function of the natural channel of comparison, the current has on the molecular structure of potassium channel cochlear , electrophysiological characteristics, pharmacological properties, and so has the pathological mechanism of a comprehensive and deep understanding. with the process of aging society, age-related hearing loss (Age-related hearing loss, ARHL the problem is becoming increasingly prominent, physical and mental health patients have a significant impact. seriously affect their quality of life. now that the generation of reactive oxygen species in vivo, removal, use of ion channels of inner ear disorders and related damage. 1 Biological characteristics of potassium channel cochlear 1.1 The molecular basis of K + channels, types and their physiological function in ion channels, K + channel is the largest family, is a hot area of #8203;#8203;clinical and scientific research. At present the relevant K + channel and multi-level naming and classification of subtypes only mammals that as many as 50 biological species, and the continued emergence of new name has more than any other ion channel structure, type and function. K + channels mainly by four shaker glycoprotein (subunit 4) forms, high degree of homology between each other. According to different biological, sbake