Research on quality control of compound Danshen preparations.docVIP

 PAGE \* MERGEFORMAT 12 Research on quality control of compound Danshen preparations Author: Xi-Ru Huang, Fan Gui-min, Fengyuan Yuan, Yang Ya-jun Keywords: Danshen;,, preparation;,, protocatechuic aldehyde;,, the total water-soluble phenolic acids;,, colorimetry Abstract: Objective To establish a water-soluble phenolic acids in Danshen preparations determination of the total approach to the total phenolic acids which serve as indicators of quality control, full control of drug quality. Methods of water-soluble phenolic acids in Danshen components and NaNO2-Al (NO3) 3 under alkaline conditions of the color reaction, colorimetric determination of water-soluble phenolic acids in Danshen preparations (in protocatechuic aldehyde dollars) the total amount. Results protocatechuic aldehyde in the 3.336 ~ 14.46 μg / ml showed good linearity within the relationship, regression equation: A = 0.027 77C 0.012 79 (r = 0.099 96), plus sample average recovery was 99.95%, RSD 0.16 %. Conclusion The method is simple, rapid and accurate, reproducible, and can be used for quality control of compound Danshen preparations. Keywords: Danshen; preparation; protocatechuic aldehyde; total amount of water-soluble phenolic acids; colorimetry Studies on Quality Control Method of Compound Radix Salviae Miltiorrhizae Preparations Abstract: ObjectiveTo establish an assay for the determination of the total components of water-soluble phenolic acidity in compound Danshen preparation.MethodsIn the solvent of 1 mol / L NaOH, using the reaction of the total components of water-soluble phenolic acidity in Danshen and the NaNO2-Al (NO3) 3, the total components of water-soluble phenolic acidity in compound Danshen preparation (calculated with protocatechualdehyde) were determined by colorimetric spectrophotometry.ResultsThe linear range of protocatechualdehyde was over 3.336 ~ 14.46 μg / ml, the correlative equation was: A = 0.027 77C 0.012 79 (r = 0.999 6). The aver