Rubescens pharmacological effects and clinical application.docVIP

 PAGE \* MERGEFORMAT 8 Rubescens pharmacological effects and clinical application Of: universal Zhou Xia Weidong Yun Dai Hua Liu [Keywords:] Hara clinical pharmacology Rubescens, also known as ice grass (Rabdosia rubescens (Hamst, Department of Isodon Labiatae species, taste joys, slightly cold. The whole plant is a folk herbal medicine, with heat and detoxifying, anti-inflammatory pain, stomach and blood and other effects . chemical composition analysis confirmed that Hara containing from monoterpenes, sesquiterpenes, diterpenes, triterpenes, volatile oil, glycosides and polysaccharides, such as a variety of substances [1]. rubescens leaves extract from isolated five types of diterpenoids, namely Hara A, B, C, D and E elements, its main anti-cancer active ingredients. nearly 30 years, and the same domestic and foreign scholars rubescens in many aspects of plants . In this paper, the pharmacological effects and clinical Rabdosia the research progress of the application of a more comprehensive review. A pharmacological effect 1.1 The anti-tumor effect 1.1.1 In vitro anti-cell proliferation was found oridonin and 109 B on human esophageal cancer cell lines and human liver cancer BEL-7402 cells were significantly cytotoxic effect [2]. Oridonin factors can prolong the Ehrlich ascites carcinoma, sarcoma S180, the survival of ascites liver cancer, long-term survival of some animals, but the leukemia (L615), lymphatic sarcoma ascites 1 (L1) and brain (B-22) no significant activity [3]. rubescens B on Ehrlich ascites carcinoma in vitro ascites (ECA) Tumor Cell significant cytotoxicity, and the effect is greater than a factor of leukemia (L615 ascites and lymphoma 1 have a certain effect, along with obvious anti-liver metastasis in Lewis lung cancer [4]. 1.1.2 inhibit cancer cell DNA, RNA and protein synthesis inhibition oridonin DNA, RNA and protein synthesis, but inhibition of its DNA to the time before the valley of RNA and protein synthesis inhi