S1 antigen and hepatitis B before the serum markers (hepatitis B five) Clinical significance of combined detection.docVIP

 PAGE \* MERGEFORMAT 7 S1 antigen and hepatitis B before the serum markers (hepatitis B five) Clinical significance of combined detection [Abstract] Objective The combined detection of serum hepatitis B virus infection with hepatitis B antigen before the S1 four models of the relationship between five common analysis to understand the former S1 antigen (PreS1) Hepatitis B virus diagnosis, treatment and prognosis value. Methods of serum hepatitis B virus infection in a total of 357 cases, using ELISA, before the S1 antigen and its serum markers of hepatitis B (HBV five) joint detection. Analysis of the “five hepatitis B” and before the S1 antigen relationship. results in HBeAg-positive HBV PrS1 antigen group was higher than that in HBeAg-negative group, the detection rate (P lt;0.01), and HBeAg negative HBV PreS1 antigen group is still 42.9% detection rate, indicating that some HBeAg-negative patients still virus replication. Conclusion PreS1 to reflect the sensitive replication of hepatitis B virus, in particular, can reflect whether the HBeAg-negative hepatitis B patients with viral replication, the “hepatitis B five” test has important complementary role, as early diagnosis of HBV infection, replication of the key indicators, carried out in the clinical laboratory. [Keywords:] Hepatitis B; hepatitis B virus pre S1 antigen; HBeAg; viral replication China is a high incidence of hepatitis B virus infection rate of 10% ~ 15%, HBeAg-positive carriers with 1.2 million or more, and thus seek rapid sensitive and specific detection methods for hepatitis B diagnosis and treatment is particularly important. Long-term Since the serum markers (hepatitis B five) has been used as hepatitis B virus (HBV) infection, replication, prognosis, an important indicator of outcome. As antigen of hepatitis B virus pre S1 (PreS1) in the pathogenesis of hepatitis B virus infection and replication aspects of research, people gradually realize that before the S1 antigen of hepati