Screening of the use of spherical symmetry design optimization of famciclovir tablet prescription.docVIP

 PAGE \* MERGEFORMAT 9 Screening of the use of spherical symmetry design optimization of famciclovir tablet prescription Author: Chen earth, Liang Dong-hong, ZHANG Shao-chun [Keywords:] famciclovir;,, dispersible tablets;,, optimization;,, spherical symmetry design Abstract: Objective: Using the spherical symmetry design method to optimize the prescription. Methods: In order to investigate dispersion uniformity index, select the main factors affecting the quality of dispersible tablets for spherical tests, and further optimize the prescription of screening. Results: According to optimize the preparation of famciclovir, dispersible tablets prescription can 3min completely collapse. Conclusion: The optimal prescription famciclovir tablet dissolution rate of better than ordinary tablets. Keywords: famciclovir; tablet; optimization; spherical symmetric design Optimization of the Formulae of Famciclovir Dispersible Tablet by Spherical Symmetric Design Abstract: Objective: To optimize the formulae by Spherical Symmetric design test. Method: The formulae of Famciclovir dispersible tablet were optimized in terms of disintegrating time by Spherical Symmetric design test. Result: The optimized Famciclovir dispersible tablet disintegrated in 3min. Conclusion: The in -vitro dissolubility of the optimized dispersible tablet is better than that of common tablet. Keywords:: Famciclovir; Dispersible tablet; Optimization; Spherical Symmetric design Famciclovir with broad-spectrum antiviral activity against herpes virus, hepatitis B virus, cytomegalovirus, EB virus are active in clinical practice is mainly used for herpes simplex, herpes zoster, genital herpes, hepatitis B treatment [1 ~ 3]. To further enhance the bioavailability of drugs, improve patient compliance, to make the drug more widely used in clinical, it is proposed famciclovir tablet is made to further enhance the in vitro dissolution. In order to optimize the prescription, the proposed design method using s