SDF-1-CXCR4 the relationship between malignant tumors and blood systems research.docVIP

 PAGE \* MERGEFORMAT 29 SDF-1/CXCR4 the relationship between malignant tumors and blood systems research Abstract stromal cell-derived factor (SDF-1) and its receptor CXCR4 interaction of a specific signal transduction in many physiological and pathological processes have played an important effect. CXCR4 in a variety of hematological tumors, high expression, and disease prognosis, drug resistance, relapse is closely related. With SDF-1 antibodies or CXCR4 antibody can effectively inhibit tumor cell growth, for the treatment of blood system cancer has opened up new avenues. In this paper, SDF-1/CXCR4 in the blood system tumors, and its prognosis, drug resistance, relapse and treatment of the relationship between the research are reviewed. Keywords: SDF-1; CXCR4; hematological neoplasms; 12G5 Research Advance on SDF-1/CXCR4 Axis Associated with Hematological Malignancies - Review Depatment of Hematology, Clinical Medical College, Southeast University, Nanjing 210009, China AbstractThe stromal cell-derived factor 1 (SDF-1) interacts with its receptor CXCR4 to transduction signals, playing important roles in most physiological and pathological processes. It is reported that CXCR4 is highly expressed in many kinds of hematological malignancies and closely related to the prognosis, drug resistance and relapse of deseases. The growth of tumor cells can be inhibited by the anti-SDF-1 antibody or anti-CXCR4 antibody, supporting a new way for the therapy against hematological malignancies. Their expression in relation with prognosis and drug resistance of hematological malignancies are summarized in this review. Keywords:SDF-1; CXCR4; hematological malignancy; 12G5 Stromal cell-derived factor (stroma cell-derived factor 1, SDF-1) and its specific receptor CXCR4 role involved not only in embryos, blood vessels, nerves, heart shape, is also involved in T, B and other immune cells and hematopoietic stem cells and migration of