Seabuckthorn on rat models of Alzheimers disease.docVIP

 PAGE \* MERGEFORMAT 10 Seabuckthorn on rat models of Alzheimer’s disease [Abstract] Objective To study Alzheimer’s disease model rats of Seabuckthorn on learning and memory ability and brain SOD (superoxide dismutase, SOD activity and MDA (malondialdehyde, MDA content, for the development and clinical application of sea buckthorn provide scientific theoretical basis. Methods intraperitoneal injection of D-galactose, 9 weeks, the establishment of Wistar rats after subacute aging model, the first 4 weeks, A25-35 into the hippocampus of rat brain, the establishment of Alzheimer’s disease (Alzheimer’s disease, AD) model . into the mold began after 2 weeks of seabuckthorn and brain rehabilitation for 8 weeks. behavior detected by Morris water maze learning and memory in rats, measured in brain SOD activity and MDA content. Results Behavioral results showed that the model rats significantly decreased learning and memory (P lt;0.05), learning and memory drug group shows significantly increased (P lt;0.05), drug group and model group, brain tissue SOD activity was significantly enhanced (P lt;0.05), MDA content was decreased (P lt;0.01. Conclusion Seabuckthorn can improve learning and memory in Alzheimer’s disease in rats the ability to reduce free radical damage to the body. [Keywords:] Alzheimer’s disease, sea buckthorn, learning and memory ability, superoxide dismutase, malondialdehyde Liu, also known as sea buckthorn vinegar, acid sting son, for the plant Elaeagnaceae Hippophae Hippophae rhamnoides L., the chemical ingredients are flavonoids, terpenoids, steroids, vitamins, proteins and amino acids, volatile oils and fatty acids class, organic acids, sugars and trace elements, is a nutrient-rich, high value medicinal plants. Seabuckthorn on the heart, brain and vascular system diseases and digestive diseases with a significant effect on the liver has a protective effect You can also clear the body of free radicals and anti-aging [1,2]. In this experiment,