Selaginella treatment on insulin resistance in the active site screening.docVIP

 PAGE \* MERGEFORMAT 9 Selaginella treatment on insulin resistance in the active site screening Of: Fu Xueyan Lin Ma Xueqin Ding Xiaoli Dong [Abstract] Objective To screen Selaginella treatment of insulin resistance in the active site. Methods AB-8 macroporous resin column chromatography eluting prepared parts of different polarity (water washing part of the group, 50% ethanol wash part of the group, 95% ethanol wash part of the group) and the water extract group, high fat diet animal model of insulin resistance, blood glucose, fasting insulin, calculated insulin sensitivity index, the active site filter Selaginella. Results of water extract of Selaginella and macroporous resin 50 % ethanol can reduce some of fasting insulin (P lt;0.01), increased ISI (P lt;0.05). Conclusion The water extract of Selaginella and macroporous resin, 50% ethanol elution were on insulin resistance in some significant mitigation effect. [Keywords:] Selaginella active site of insulin resistance Selaginellaceae as Selaginella Selaginella Selaginella tamariscina (Beauv.) Spring and cushion Selaginella S.pulvinata (Hook.et Grev.) Maxim. The whole plant, the genus of about 60 to 70. With the blood the effectiveness of the Classics for amenorrhea dysmenorrhea, Zheng Jia lump in the abdomen, or flutter injury, after speculation of carbon addiction to stop bleeding, for vomiting blood, bleeding, blood in the stool, rectal prolapse. [1] reported in the literature [2] Selaginella water extract more fructose meal animal model of insulin resistance improved significantly the role, but not reflected in its material basis for the role of the relevant reports. In this experiment, the active site of the insulin sensitivity index as an indicator to screen the treatment of insulin resistance Selaginella the active site for further separation and mechanisms of the composition to provide experimental basis. 1 Materials and methods 1.1 SD rats of clean grade animal, male, weighing 180 ~