Telomeres and aging progress in epidemiological studies.docVIP

 PAGE \* MERGEFORMAT 20 Telomeres and aging progress in epidemiological studies Study: Fruit Ju Zhenyu Xiao Xiao Feng Bow-Wen Chen G [Keywords:] telomere, hypertension, coronary heart disease, diabetes, Alzheimer’s Aging of a series of social problems will affect China’s economic development, slowing the aging can prevent and reduce disease incidence and prevalence of a variety of old age, thus saving a lot of health resources and social wealth. Senescence as a phenomenon of life, from genetic common cause with the environment, aging and hypertension, type 2 diabetes, atherosclerosis, Alzheimer’s, heart disease, cerebrovascular accidents and other closely related. of how to slow aging, by foreseeing the occurrence of targeted, individualized prevention change the environment may intervene to prevent the risk factor can be “healthy aging” as a possible direction of the medical necessity of the development. telomere is considered the biological clock of cell senescence, however, whether telomerase can be used as a sign of human aging is also controversial. In this study, community resources and people combine molecular biology techniques to study telomeres and the relationship between social environmental factors, to whether the telomere of human aging and related diseases as a biological marker for a brief overview. A telomeres and telomerase Telomeres are DNA ends of linear chromosomes of a protective structure, composed of proteins and telomeric DNA, telomere DNA is simple sequence repeat of human telomeres by the 5 ‘TTAGGG 3’ repeat sequence composition, functions do not have any protein coding . Every time DNA replication are associated with telomere loss and telomere shortening is considered to be the biological clock of cell division (1). telomeres has important biological functions: stability of chromosomes, to prevent chromosome end fusion, protection of chromosome structure gene, determine cell life. the aging process of progressive t