The relationship between gene polymorphisms and susceptibility to pulmonary tuberculosis Research Progress.docVIP

 PAGE \* MERGEFORMAT 35 The relationship between gene polymorphisms and susceptibility to pulmonary tuberculosis Research Progress 【Key Words】 Tuberculosis, pulmonary; gene Tuberculosis is the world’s largest by a single pathogen fatal disease, every year some 3 million people die of TB, or about every 10 seconds another person dies of tuberculosis. There are around 1 / 3 of people infected with TB bacilli, but less than 1 / 10 developed tuberculosis, reason, in addition to a small number of these patients have significant risk factors such as the AIDS virus (HIV) infection, diabetes, and application of hormone substandard treatment, most of the rest by genetic factors (genetic polymorphism) and environmental factors together results. In recent years, tuberculosis and genetic susceptibility factors (genetic polymorphism) the relationship between the extensive research, are summarized as follows. A human natural resistance-associated macrophage protein 1 (NRAMP1) gene polymorphisms associated with TB NRAMP1 gene is located in the late resting macrophage intracellular cavity, in macrophages after phagocytosis of pathogens and transferred to the phagosome membrane [1]. NRAMP1 may be swallowed by changing the environment within the lysosomes, limiting the propagation of intracellular pathogens [2]. The results showed that [3], NRAMP1 gene polymorphisms in multiple sites, their different genotypes may affect the host resistance against Mycobacterium tuberculosis. Bellamy et al [4] The results showed that, NRAMP1 gene INT4, D543N and 3’UTR three polymorphic loci with the African tuberculosis were significantly related to sex, and the existence of ethnic differences in genotype frequencies. My Anja Chen Deng [5] studies have shown that: NRAMP1 gene 3’UTR polymorphisms may be in northern Chinese Han adult TB risk factors, while the INT4 polymorphism may be related to the nature of the relationship between lesions of tuberculosis. L