Tianma injection of the pharmacological effects and clinical application of.docVIP

 PAGE \* MERGEFORMAT 22 Tianma injection of the pharmacological effects and clinical application of [Keywords:] Tianma Injection Clinical Pharmacology Gastrodia orchids, from Gastrodia to extract the chemical ingredients are gastrodin, gastrodin yuan, Vanilla alcohol, Vanilla aldehyde, Tianma ether glycoside, p-hydroxybenzaldehyde, citric acid, succinic acid and so on. In which the highest content of active ingredients of effective monomer component is gastrodin (chemical name of the hydroxymethyl phenyl-β -D-glucopyranoside, also known as gastrodin) [1]. In this paper, the pharmacological effects Gastrodia injection and clinical applications are summarized below. A pharmacological effect gastrodin 1.1 The role of sedative-hypnotic use of intravenous injection of experimental monkeys gastrodin 50 mg / kg, 20 min after emergence quiet, no nervous kind, duration up to 2 h. The experimental mice were injected subcutaneously gastrodin The results showed that significant synergistic gastrodin sodium pentobarbital, chloral hydrate, and the role of thiopental and so on. Gastrodin can antagonize the caffeine-induced excitability role and significantly prolong the hypnotic dose of pentobarbital sodium in mice of sleep time. Rhesus monkeys, rabbits and pigeons, after intravenous injection of gastrodin was producing sedation. Gastrodin through blood-brain barrier, in the brain tissue at a higher rate of degradation of gastrodin million yuan for the brain cell membrane gastrodin Bz receptor ligands. Therefore, gastrodin yuan acting on γ -amino butyric acid / Bz receptor, thus demonstrating the sedative, anti-convulsion of the central inhibitory effect [2]. 1.2 anticonvulsant effect in mice by intraperitoneal injection gastrodin 30 mg / kg, 30 min after the intravenous infusion of 0.5% pentylenetetrazol solution 30 mg / kg, results showed that gastrodin could extend pentylenetetrazol clonic seizures of the incubation period, a clear against pentylenetetrazol clonic con