UUO kidney of melatonin on oxidative damage induced by the impact of changes and blood rheology.docVIP

 PAGE \* MERGEFORMAT 24 UUO kidney of melatonin on oxidative damage induced by the impact of changes and blood rheology Of: Liu Changming, Hua Chunxiu, Li was China [Abstract] Objective of melatonin on unilateral ureteral obstruction (Unilateral ureteral obstruction, UUO) induced renal oxidative damage and hemorheology of the body. Methods adult female SD 30 rats were randomly divided into three groups: sham operation group (Sham, model group (UUO and melatonin groups (Mel 10 in each. UUO group and Mel groups left ureteral ligation, Sham group did not undergo the ureter. Mel group was given intraperitoneal injection of Mel (10 mg / kg d, UUO group and the Sham group were given equal volume of saline containing 5% ethanol solution, continuous 14d, the check detection of renal cortical malondialdehyde (alondialdehvde, MDA) content, superoxide dismutase (superoxide dismutase, SOD ) activity, abdominal aortic blood rheology testing body. Results UUO group compared with the Sham group, MDA content increased in kidney tissue, SOD activity decreased blood viscosity, plasma viscosity and whole blood reduced viscosity l high hematocrit, red blood cell count and erythrocyte aggregation index decreased, Mel group and UUO group, the kidney was decreased in renal tissue MDA, SOD activity increased red blood cell count and hematocrit increases blood viscosity and whole blood reduced viscosity. Conclusion Mel can reduce renal oxidative stress induced by UUO and UUO caused by the body to improve blood rheology changes, indicating that mel obstructive renal injury has obvious protective effect. [Keywords:] melatonin; unilateral ureteral obstruction; oxidative stress; hemorheology Abstract Objective To study the effect of melatonin on renal oxidation damage and on the change of body hemorrheology induced by unilateral ureteral obstruction (UUO). Methods 30 female adult Sprague-Dawley rats were randomly divided into 3 groups: sham group, UUO group and melatonin group