mFOLFOX6方案与CapeOX方案治疗老年转移性结直肠癌临床疗效分析.pdfVIP

实用临床医药杂志 2013 年第 17 卷第 13 期 Joumal of Clinical Medicine in Practice • 33 . mFOLFOX6 方案与 CapeOX 方案治疗老年转移性 结直肠癌临床疗效分析 周慧俊，殷先利，刘振洋，李 勇 (中南大学湘雅医学院附属肿瘤医院消化泌尿内科，湖南长沙， 410013) 摘要:目的观察mFOLfDX6 方案与CapeOX 方案治疗老年转移性结直肠癌的临床疗效及不良反应。方法 将 168 例发生转移的老年结直肠癌患者随机分为2 组，mFOLFOX6 组 82 倒接受奥沙利铅+亚叶酸钙+5氟尿嗜睫治疗，Ca醉。X组 86 例接受奥沙利铅+卡培他滨治疗。 2 组均至少治疗2 个周期。比较2 组临床疗效及不良反应。结果 2 组总有效率、中位 疾病进展时间及中位生存期无显著差异。 2 组不良反应主要包括口腔秸膜炎、神经毒性、腹泻、恶心呕吐、白细胞减少、中性粒 细胞减少和转氨酶升高，且以 1-11 度为主。mFOLFOX6 组囚 -N度中性粒细胞减少率显著高于CapeOX组，但 ca萨οX组手 足综合征发生率显著高于mFOLFOX6 组。结论 mFOLFOX6 方案与Cap的X 方案治疗老年转移性结直肠癌疗效相当，且不 良反应均能耐受，但Cap的X 方案用药更方便，更适合体质较弱的老年患者或门诊接受化疗的患者。 关键词: 5-氟尿略院;亚叶酸钙;奥沙利销;卡培他滨;老年;转移性结直肠癌 中图分类号: R 735.3 文献标志码:A 文章编号: 1672-2353(2013) 13-033-04 目光 10. 7619 1jcmp. 201313011 Clinical effects of mFOLFOX6 and CapeOX regimens for senile metastatic colorectal cancer ZHOU Huijun , YIN Xianli , LIU Zhenyang , LI Yong ( The Affiliated Turrwr Hospi时ofX叩zg)U Medical School of Central 岛uth Uniærsity , αangsha ， Hunan , 410043) ~TRAcr: Obj配tive To observe the clinical effects and adverse reactions of mFOLFOX6 regimen as well as CapeOX in the treatment of senile metastatic colorectal cancer. Meth创S One hundred and eight-six patients with senile metastatic colorectal cancer were randomly divided into two groups. Eight-two ca民s in mFOLFOX6 group were treated with oxaliplatin + calcium folinatc + 5-fluorouracil , while another 86 in CapeOx group with oxaliplatin + capecitabine. Both groups were treated for at least two weeks. The clinical effects and adverse reactions in two groups were ∞mpared.R臼ults There were no significant differences ∞mpared with the total effectiveness